Theresa Foster’s research featured on cover of chemistry journal

91AV Pharmacy graduate student Theresa Foster (’13) is the first author on a research article that has been published in and featured on the cover of the September 2012 volume of the Journal of Computational Chemistry.  Foster worked with two co-authors: Assistant Professor and Vice-Chair of the Pharmaceutical Science Department Olgun Guvench, M.D., Ph.D., as well as University of Maryland School of Pharmacy researcher Alexander Mackerell. 

The article, “Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery,” discusses the researchers’ findings in the area of computer-aided drug design.The findings demonstrate the utility of the SILCS (Site Identification by Ligan Competitive Saturation) computational fragment-based drug design technology, previously developed by Guvench and Mackerell, for finding hidden druggable hot-spots in challenging targets, such as those involved in protein-protein
 

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